Adipose tissue macrophages: their role in adipose tissue remodeling
نویسندگان
چکیده
منابع مشابه
Macrophages – The Key Actors in Adipose Tissue Remodeling and Dysfunction
Adipose tissue (AT) is a very important endocrine and paracrine organ that regulates oth‐ er tissues and organs. Dysfunction of AT leads to a wide range of disorders like obesity, insulin resistance, diabetes mellitus, cardiac disorders, tumors and others. Adipose tissue macrophages (ATMs) are the key actors in AT remodeling and dysfunction. Their role in AT dysfunction is nowadays increasingly...
متن کاملAdipose tissue remodeling and obesity.
To fulfill its role as the major energy-storing tissue, adipose has several unique properties that cannot be seen in any other organ, including an almost unlimited capacity to expand in a non-transformed state. As such, the tissue requires potent mechanisms to remodel, acutely and chronically. Adipocytes can rapidly reach the diffusional limit of oxygen during growth; hypoxia is therefore an ea...
متن کاملRemodeling phenotype of human subcutaneous adipose tissue macrophages.
BACKGROUND Adipose tissue macrophages (ATMs) have become a focus of attention recently because they have been shown to accumulate with an increase in fat mass and to be involved in the genesis of insulin resistance in obese mice. However, the phenotype and functions of human ATMs are still to be defined. METHODS AND RESULTS The present study, performed on human subcutaneous AT, showed that AT...
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Chronic overnutrition drives complex adaptations within both professional metabolic and bystander tissues that, despite intense investigation, are still poorly understood. Xu et al. (2013) now describe the unexpected ability of adipose tissue macrophages to buffer lipids released from obese adipocytes in a manner independent of inflammatory macrophage activation.
متن کاملMitochondrial homeostasis in adipose tissue remodeling.
Mitochondrial homeostasis is regulated by a balance between mitochondrial biogenesis and degradation. Emerging evidence suggests that mitophagy, a selective form of autophagy that degrades mitochondria, plays a key role in the physiology and pathophysiology of mitochondria-enriched cells, such as brown and beige adipocytes. This review discusses findings regarding the roles of autophagy and mit...
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ژورنال
عنوان ژورنال: Journal of Leukocyte Biology
سال: 2010
ISSN: 0741-5400
DOI: 10.1189/jlb.0210072